Water soluble azo dyes and their synthesis and use

专利名称：Water soluble azo dyes and their synthesis

and use

发明人：Han-chul Song,Kwang-nak Koh,Shin-won

Kang,Jin-ho Cho,Joohg-hun Kim,Su-mi Lee

申请号：US09/436865申请日：19991109公开号：US06046312A公开日：20000404

摘要：Disclosed are water soluble azo dyes, represented by Formula I or II, and theirsynthesis and use. The water soluble azo dyes are synthesized by diazotizing 4-aminopyridine and coupling the resulting diazo intermediate with alkylated metanilic ororthanilic acid. To be suitable for measuring blood glucose levels, the dyes are combinedwith m- nitrophenyl boronic acid in an aqueous solvent. A combined ao form of the dyeswith glucose shows a peak at 540 nm. At this wavelength, the absorptivity has a tendencyto increase with the increasing of glucose level, which allows the measurement of bloodglucose levels. ##STR1## wherein R has a 1-4 carbon atom length and is an alkyl, ahydroxy alkyl, a carboxyl-containing alkyl, or a sulfonyl-containing alkyl.

申请人：DONGIL TECHNOLOGY LTD.

代理机构：Darby & Darby

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